Ontology highlight
ABSTRACT:
SUBMITTER: Wenzler E
PROVIDER: S-EPMC4978611 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Wenzler Eric E Fraidenburg Dustin R DR Scardina Tonya T Danziger Larry H LH
Clinical microbiology reviews 20160701 3
Gram-negative organisms comprise a large portion of the pathogens responsible for lower respiratory tract infections, especially those that are nosocomially acquired, and the rate of antibiotic resistance among these organisms continues to rise. Systemically administered antibiotics used to treat these infections often have poor penetration into the lung parenchyma and narrow therapeutic windows between efficacy and toxicity. The use of inhaled antibiotics allows for maximization of target site ...[more]