Self-Administered Nicotine Suppresses Body Weight Gain Independent of Food Intake in Male Rats.

ABSTRACT:

Introduction

The action of nicotine to suppress body weight is often cited as a factor impacting smoking initiation and the failure to quit. Despite the weight-suppressant effects of nicotine, smokers and nonsmokers report equal daily caloric intake. The weight-suppressive effects of nicotine in animal models of smoking are poorly understood. Furthermore, the Food and Drug Administration has authority to implement a policy markedly reducing nicotine levels in cigarettes; such a reduction could reduce smoking behavior, but have detrimental effects on body weight. The aim of this investigation was to examine the effects of self-administered nicotine on body weight and food intake in rats.

Methods

In Experiment 1, rats with ad libitum access to chow responded for intravenous in

SUBMITTER: Rupprecht LE 

PROVIDER: S-EPMC4978984 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature