Scalable hybrid chemical manufacture to photothermal therapy: PEG-capped phototransducers.

ABSTRACT: Ag-TiO2@polyethylene glycol (PEG) nanoparticles were continuously obtained in a single-pass configuration by appropriately reacting freshly flame-synthesized TiO2 with Ag formed in an ultrasonic aqueous medium containing PEG. When the proposed synthesis was kept constant, the production rate for Ag-TiO2@PEG nanoparticles reached approximately 3 g/h while only using a combination of a lab-scale inverse-diffusion flame (16 mm head diameter) and an ultrasonic Ag(I) cell (50 mL). The synthesized nanoparticles were employed as inducers for in vitro photoinduced therapy to kill cancer cells at different light wavelengths. Measurements of the nanoparticle cytotoxicity revealed that PEG incorporation with the Ag-TiO2 particles significantly decreased the cytotoxicity (cell viability of more than ~

SUBMITTER: Byeon JH 

PROVIDER: S-EPMC4979092 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature