Dataset Information

The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study.

ABSTRACT:

Introduction

The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers.

Methods

In this case-control study, we report the antihypertensive drugs-breast cancer relationship in 1,736 breast cancer cases and 1,895 healthy controls; results are reported stratifying by the women's characteristics (i.e., menopausal status or body mass index category) tumor characteristics and length of use of antihypertensive drugs.

Results

The relationship among breast cancer and use of calcium channel blockers (CCB) for 5 or more years had odds ratio (OR) = 1.77 (95% CI, 0.99 to 3.17). Stratifying by BMI, the OR increased significantly in the group with BMI ≥ 25 (OR 2.54, 95% CI, 1.24 to 5.22). CCBs were even more strongly associated with more aggressive tumors, (OR for invasive tumors = 1.96, 95% CI = 1.09 to 3.53; OR for non ductal cancers = 3.97, 95% CI = 1.73 to 9.05; OR for Erbb2+ cancer = 2.97, 95% CI: 1.20 to 7.32). On the other hand, premenopausal women were the only group in which angiotensin II receptor blockers may be associated with breast cancer (OR = 4.27, 95% CI = 1.32 to 13.84) but this could not be identified with any type or stage. Use of angiotensin-converting-enzyme inhibitors, beta blockers and diuretics were not associated with risk.

Conclusions

In this large population-based study we found that long term use of calcium channel blockers is associated with some subtypes of breast cancer (and with breast cancer in overweight women).

SUBMITTER: Gomez-Acebo I

PROVIDER: S-EPMC4979888 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study.

Gómez-Acebo Inés I Dierssen-Sotos Trinidad T Palazuelos Camilo C Pérez-Gómez Beatriz B Lope Virginia V Tusquets Ignasi I Alonso M Henar MH Moreno Victor V Amiano Pilar P Molina de la Torre Antonio José AJ Barricarte Aurelio A Tardon Adonina A Camacho Antonio A Peiro-Perez Rosana R Marcos-Gragera Rafael R Muñoz Montse M Michelena-Echeveste Maria Jesus MJ Ortega Valin Luis L Guevara Marcela M Castaño-Vinyals Gemma G Aragonés Nuria N Kogevinas Manolis M Pollán Marina M Llorca Javier J

PloS one 20160810 8

<h4>Introduction</h4>The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers.<h4>Methods</h4>In this case-control study, we report the antihypertensive drugs-breast cancer relationship in 1,736 bre ...[more]

PMID: 27508297

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Dataset Information

The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study.

Introduction

Methods

Results

Conclusions

Publications

The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study.

Similar Datasets

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