Ontology highlight
ABSTRACT:
SUBMITTER: Carpenter B
PROVIDER: S-EPMC4979997 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Carpenter Byron B Nehmé Rony R Warne Tony T Leslie Andrew G W AG Tate Christopher G CG
Nature 20160727 7614
G-protein-coupled receptors (GPCRs) are essential components of the signalling network throughout the body. To understand the molecular mechanism of G-protein-mediated signalling, solved structures of receptors in inactive conformations and in the active conformation coupled to a G protein are necessary. Here we present the structure of the adenosine A(2A) receptor (A(2A)R) bound to an engineered G protein, mini-Gs, at 3.4 Å resolution. Mini-Gs binds to A(2A)R through an extensive interface (1,0 ...[more]