T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression.
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ABSTRACT:
SUBMITTER: Abdul-Wajid S
PROVIDER: S-EPMC4980084 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression.
Abdul-Wajid Sarah S Morales-Diaz Heidi H Khairallah Stephanie M SM Smith William C WC
Cell reports 20151017 4
A major class of human birth defects arise from aberrations during neural tube closure (NTC). We report on a NTC signaling pathway requiring T-type calcium channels (TTCCs) that is conserved between primitive chordates (Ciona) and Xenopus. With loss of TTCCs, there is a failure to seal the anterior neural folds. Accompanying loss of TTCCs is an upregulation of EphrinA effectors. Ephrin signaling is known to be important in NTC, and ephrins can affect both cell adhesion and repulsion. In Ciona, e ...[more]
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