Ontology highlight
ABSTRACT:
SUBMITTER: Wachter E
PROVIDER: S-EPMC4980196 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Wachter Erin E Zamora Ana A Heidary David K DK Ruiz José J Glazer Edith C EC
Chemical communications (Cambridge, England) 20160801 66
Two thermally activated ruthenium(ii) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1-9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research. ...[more]