Ontology highlight
ABSTRACT:
SUBMITTER: Lin YH
PROVIDER: S-EPMC4980623 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20160811
The development of a ligand that is capable of distinguishing among the wide variety of G-quadruplex structures and targeting telomeres to treat cancer is particularly challenging. In this study, the ability of two anthraquinone telomerase inhibitors (NSC749235 and NSC764638) to target telomeric G-quadruplex DNA was probed. We found that these ligands specifically target the potassium form of telomeric G-quadruplex DNA over the DNA counterpart. The characteristic interaction with the telomeric G ...[more]