An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
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ABSTRACT:
SUBMITTER: Horvath S
PROVIDER: S-EPMC4980791 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
Horvath Steve S Gurven Michael M Levine Morgan E ME Trumble Benjamin C BC Kaplan Hillard H Allayee Hooman H Ritz Beate R BR Chen Brian B Lu Ake T AT Rickabaugh Tammy M TM Jamieson Beth D BD Sun Dianjianyi D Li Shengxu S Chen Wei W Quintana-Murci Lluis L Fagny Maud M Kobor Michael S MS Tsao Philip S PS Reiner Alexander P AP Edlefsen Kerstin L KL Absher Devin D Assimes Themistocles L TL
Genome biology 20160811 1
<h4>Background</h4>Epigenetic biomarkers of aging (the "epigenetic clock") have the potential to address puzzling findings surrounding mortality rates and incidence of cardio-metabolic disease such as: (1) women consistently exhibiting lower mortality than men despite having higher levels of morbidity; (2) racial/ethnic groups having different mortality rates even after adjusting for socioeconomic differences; (3) the black/white mortality cross-over effect in late adulthood; and (4) Hispanics i ...[more]
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