Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed NS
PROVIDER: S-EPMC4980833 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Ahmed Nermin S NS Gary Bernard D BD Piazza Gary A GA Tinsley Heather N HN Laufer Stefan S Abadi Ashraf H AH
Medicinal chemistry (Shariqah (United Arab Emirates)) 20101101 6
Starting from a previously reported lead compound GR30040X (a hydantoin tetrahydro-β-carboline derivative with a 4- pyridinyl ring at C- 5), a series of structurally related tetrahydro-β-carboline derivatives were prepared. The tetrahydro-β-carboline skeleton was fused either to a hydantoin or to a piperazindione ring, the pendant aryl group attached to C-5 or C-6 was changed to a 3, 4-dimethoxyphenyl or a 3-pyridinyl ring; different N-substituents on the terminal ring were introduced, a straigh ...[more]