Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC4981060 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Chen Yu Y Zhao Zhiqiang Z Bian Zheng Z Jin Rizhe R Kang Chuanqing C Qiu Xuepeng X Guo Haiquan H Du Zhijun Z Gao Lianxun L
ChemistryOpen 20160427 4
The motivation of foldamer chemistry is to identify novel building blocks that have the potential to imitate natural species. Peptides and peptide mimetics can form stable helical conformations and further self-assemble into diverse aggregates in water, where it is difficult to isolate a single helix. In contrast, most "abiotic" foldamers may fold into helical structures in solution, but are difficult to assemble into tertiary ones. It remains a challenge to obtain "abiotic" species similar to p ...[more]