Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females.
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ABSTRACT:
SUBMITTER: Bennett WD
PROVIDER: S-EPMC4981326 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females.
Bennett William D WD Ivins Sally S Alexis Neil E NE Wu Jihong J Bromberg Philip A PA Brar Sukhdev S SS Travlos Gregory G London Stephanie J SJ
PloS one 20160811 8
We previously observed greater ozone-induced lung function decrements in obese than non-obese women. Animal models suggest that obesity enhances ozone-induced airway reactivity and inflammation. In a controlled exposure study, we compared the acute effect of randomized 0.4ppm ozone and air exposures (2 h with intermittent light exercise) in obese (N = 20) (30<BMI<40Kg/m2) vs. non-obese (N = 20) (BMI<25Kg/m2) non-smoking 18-35 year old women. We measured spirometry and bronchial reactivity to inh ...[more]
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