Ontology highlight
ABSTRACT:
SUBMITTER: Choi JP
PROVIDER: S-EPMC4981389 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Choi Jaesung P JP Foley Matthew M Zhou Zinan Z Wong Weng-Yew WY Gokoolparsadh Naveena N Arthur J Simon C JS Li Dean Y DY Zheng Xiangjian X
PloS one 20160811 8
Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic approaches for CCM disease. However, the full value of these animal models is limited by the lack of an accurate and quantitative method to assess lesion burden and progression. In the present study ...[more]