Ontology highlight
ABSTRACT:
SUBMITTER: Padanad MS
PROVIDER: S-EPMC4981512 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Padanad Mahesh S MS Konstantinidou Georgia G Venkateswaran Niranjan N Melegari Margherita M Rindhe Smita S Mitsche Matthew M Yang Chendong C Batten Kimberly K Huffman Kenneth E KE Liu Jingwen J Tang Ximing X Rodriguez-Canales Jaime J Kalhor Neda N Shay Jerry W JW Minna John D JD McDonald Jeffrey J Wistuba Ignacio I II DeBerardinis Ralph J RJ Scaglioni Pier Paolo PP
Cell reports 20160728 6
KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coenzyme A (CoA) synthetase long-chain family member 3 (ACSL3), which converts fatty acids into fatty Acyl-CoA esters, the substrates for lipid synthesis and β-oxidation. ACSL3 suppress ...[more]