The Epigenetic Pathways to Ribosomal DNA Silencing.
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ABSTRACT:
SUBMITTER: Srivastava R
PROVIDER: S-EPMC4981667 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
The Epigenetic Pathways to Ribosomal DNA Silencing.
Srivastava Rakesh R Srivastava Rashmi R Ahn Seong Hoon SH
Microbiology and molecular biology reviews : MMBR 20160601 3
Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several ...[more]
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