The complexity of epigenetic diseases.
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ABSTRACT:
SUBMITTER: Brazel AJ
PROVIDER: S-EPMC4982038 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
The complexity of epigenetic diseases.
Brazel Ailbhe Jane AJ Vernimmen Douglas D
The Journal of pathology 20151117 2
Over the past 30 years, a plethora of pathogenic mutations affecting enhancer regions and epigenetic regulators have been identified. Coupled with more recent genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) implicating major roles for regulatory mutations in disease, it is clear that epigenetic mechanisms represent important biomarkers for disease development and perhaps even therapeutic targets. Here, we discuss the diversity of disease-causing mutations in ...[more]
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