Ontology highlight
ABSTRACT:
SUBMITTER: Bartulos O
PROVIDER: S-EPMC4982472 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Bartulos Oscar O Zhuang Zhen Wu ZW Huang Yan Y Mikush Nicole N Suh Carol C Bregasi Alda A Wang Lin L Chang William W Krause Diane S DS Young Lawrence H LH Pober Jordan S JS Qyang Yibing Y
JCI insight 20160701 10
Cardiovascular progenitor cells (CPCs) expressing the ISL1-LIM-homeodomain transcription factor contribute developmentally to cardiomyocytes in all 4 chambers of the heart. Here, we show that ISL1-CPCs can be applied to myocardial regeneration following injury. We used a rapid 3D methylcellulose approach to form murine and human ISL1-CPC spheroids that engrafted after myocardial infarction in murine hearts, where they differentiated into cardiomyocytes and endothelial cells, integrating into the ...[more]