Ontology highlight
ABSTRACT:
SUBMITTER: Ghorab MM
PROVIDER: S-EPMC4982500 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ghorab Mostafa M MM Alsaid Mansour S MS Higgins Maureen M Dinkova-Kostova Albena T AT Shahat Abdelaaty A AA Elghazawy Nehal H NH Arafa Reem K RK
Drug design, development and therapy 20160808
The Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response elements pathway enables cells to survive oxidative stress conditions through regulating the expression of cytoprotective enzymes such as<h4>Nad(p)h</h4>quinone oxidoreductase 1 (NQO1). This work presents the design and synthesis of novel anilinoquinazoline derivatives (2-16a) and evaluation of their NQO1 inducer activity in murine cells. Molecular docking of the new compounds ...[more]