Consequences of a Maternal High-Fat Diet and Late Gestation Diabetes on the Developing Rat Lung.

ABSTRACT:

Rationale

Infants born to diabetic or obese mothers are at risk of respiratory distress and persistent pulmonary hypertension of the newborn (PPHN), conceivably through fuel-mediated pathogenic mechanisms. Prior research and preventative measures focus on controlling maternal hyperglycemia, but growing evidence suggests a role for additional circulating fuels including lipids. Little is known about the individual or additive effects of a maternal high-fat diet on fetal lung development.

Objective

The objective of this study was to determine the effects of a maternal high-fat diet, alone and alongside late-gestation diabetes, on lung alveologenesis and vasculogenesis, as well as to ascertain if consequences persist beyond the perinatal period.

Methods

A rat model was u

SUBMITTER: Baack ML 

PROVIDER: S-EPMC4982689 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature