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Endocrine-specific NIR fluorophores for adrenal gland targeting.

ABSTRACT: The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable image-guided surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR image-guided resection or avoidance of the AGs during both open and minimally-invasive surgery.

SUBMITTER: Ashitate Y 

PROVIDER: S-EPMC4982771 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Endocrine-specific NIR fluorophores for adrenal gland targeting.

Ashitate Yoshitomo Y   Levitz Andrew A   Park Min Ho MH   Hyun Hoon H   Venugopal Vivek V   Park GwangLi G   El Fakhri Georges G   Henary Maged M   Gioux Sylvain S   Frangioni John V JV   Choi Hak Soo HS  

Chemical communications (Cambridge, England) 20160801 67

The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable image-guided surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR image-guided resection or avoidance of the AGs during both open and minimally-invasive surgery. ...[more]

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