Gut Microbial Metabolites Fuel Host Antibody Responses.
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ABSTRACT:
SUBMITTER: Kim M
PROVIDER: S-EPMC4982788 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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Gut Microbial Metabolites Fuel Host Antibody Responses.
Kim Myunghoo M Qie Yaqing Y Park Jeongho J Kim Chang H CH
Cell host & microbe 20160728 2
Antibody production is a metabolically demanding process that is regulated by gut microbiota, but the microbial products supporting B cell responses remain incompletely identified. We report that short-chain fatty acids (SCFAs), produced by gut microbiota as fermentation products of dietary fiber, support host antibody responses. In B cells, SCFAs increase acetyl-CoA and regulate metabolic sensors to increase oxidative phosphorylation, glycolysis, and fatty acid synthesis, which produce energy a ...[more]
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