Ontology highlight
ABSTRACT:
SUBMITTER: Rider D
PROVIDER: S-EPMC4982827 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Rider Daniel D Furusho Hisako H Xu Shuang S Trachtenberg Alexander J AJ Kuo Winston Patrick WP Hirai Kimito K Susa Mako M Bahammam Laila L Stashenko Philip P Fujimura Akira A Sasaki Hajime H
Anatomical record (Hoboken, N.J. : 2007) 20160706 9
Apical periodontitis (periapical lesions) is an infection-induced chronic inflammation in the jaw, ultimately resulting in the destruction of apical periodontal tissue. Toll-like receptors (TLRs) are prominent in the initial recognition of pathogens. Our previous study showed that TLR4 signaling is proinflammatory in periapical lesions induced by a polymicrobial endodontic infection. In contrast, the functional role of TLR2 in regulation of periapical tissue destruction is still not fully unders ...[more]