Ontology highlight
ABSTRACT:
SUBMITTER: Maj C
PROVIDER: S-EPMC4983747 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Maj Carlo C Minelli Alessandra A Giacopuzzi Edoardo E Sacchetti Emilio E Gennarelli Massimo M
Current neuropharmacology 20160101 5
Genomic studies revealed two main components in the genetic architecture of schizophrenia, one constituted by common variants determining a distributed polygenic effect and one represented by a large number of heterogeneous rare and highly disruptive mutations. These gene modifications often affect neural transmission and different studies proved an involvement of metabotropic glutamate receptors in schizophrenia phenotype. Through the combination of literature information with genomic data from ...[more]