Ontology highlight
ABSTRACT:
SUBMITTER: Long H
PROVIDER: S-EPMC4983809 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Long Hongan H Miller Samuel F SF Strauss Chloe C Zhao Chaoxian C Cheng Lei L Ye Zhiqiang Z Griffin Katherine K Te Ronald R Lee Heewook H Chen Chi-Chun CC Lynch Michael M
Proceedings of the National Academy of Sciences of the United States of America 20160418 18
Although it is well known that microbial populations can respond adaptively to challenges from antibiotics, empirical difficulties in distinguishing the roles of de novo mutation and natural selection have left several issues unresolved. Here, we explore the mutational properties of Escherichia coli exposed to long-term sublethal levels of the antibiotic norfloxacin, using a mutation accumulation design combined with whole-genome sequencing of replicate lines. The genome-wide mutation rate signi ...[more]