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Specialization versus conservation: How Pol I and Pol III use the conserved architecture of the pre-initiation complex for specialized transcription.

ABSTRACT: Here, we discuss the overall architecture of the RNA polymerase I (Pol I) and III (Pol III) core enzymes and their associated general transcription factors in the context of models of the Pol I and Pol III pre-initiation complexes, thereby highlighting potential functional adaptations of the Pol I and Pol III enzymes to their respective transcription tasks. Several new insights demonstrate the great degree of specialization of each of the eukaryotic RNA polymerases that is only beginning to be revealed as the structural and functional characterization of all eukaryotic RNA polymerases and their pre-initiation complexes progresses.

SUBMITTER: Hoffmann NA

PROVIDER: S-EPMC4984676 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Specialization versus conservation: How Pol I and Pol III use the conserved architecture of the pre-initiation complex for specialized transcription.

Hoffmann Niklas A NA Sadian Yashar Y Tafur Lucas L Kosinski Jan J Müller Christoph W CW

Transcription 20160621 4

Here, we discuss the overall architecture of the RNA polymerase I (Pol I) and III (Pol III) core enzymes and their associated general transcription factors in the context of models of the Pol I and Pol III pre-initiation complexes, thereby highlighting potential functional adaptations of the Pol I and Pol III enzymes to their respective transcription tasks. Several new insights demonstrate the great degree of specialization of each of the eukaryotic RNA polymerases that is only beginning to be r ...[more]

PMID: 27327079

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Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.

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