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Super elongation complex contains a TFIIF-related subcomplex.

ABSTRACT: Super elongation complex (SEC) belongs to a family of RNA polymerase II (Pol II) elongation factors that has similar properties as TFIIF, a general transcription factor that increases the transcription elongation rate by reducing pausing. Although SEC has TFIIF-like functional properties, it apparently lacks sequence and structural homology. Using HHpred, we find that SEC contains an evolutionarily related TFIIF-like subcomplex. We show that the SEC subunit ELL interacts with the Pol II Rbp2 subunit, as expected for a TFIIF-like factor. These findings suggest a new model for how SEC functions as a Pol II elongation factor and how it suppresses Pol II pausing.

SUBMITTER: Knutson BA

PROVIDER: S-EPMC4984678 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Super elongation complex contains a TFIIF-related subcomplex.

Knutson Bruce A BA Smith Marissa L ML Walker-Kopp Nancy N Xu Xia X

Transcription 20160525 4

Super elongation complex (SEC) belongs to a family of RNA polymerase II (Pol II) elongation factors that has similar properties as TFIIF, a general transcription factor that increases the transcription elongation rate by reducing pausing. Although SEC has TFIIF-like functional properties, it apparently lacks sequence and structural homology. Using HHpred, we find that SEC contains an evolutionarily related TFIIF-like subcomplex. We show that the SEC subunit ELL interacts with the Pol II Rbp2 sub ...[more]

PMID: 27223670

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