Ontology highlight
ABSTRACT:
SUBMITTER: Stein SM
PROVIDER: S-EPMC4984865 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Stein Stacey M SM James Edward S ES Deng Yanhong Y Cong Xiangyu X Kortmansky Jeremy S JS Li Jia J Staugaard Carol C Indukala Doddamane D Boustani Ann Marie AM Patel Vatsal V Cha Charles H CH Salem Ronald R RR Chang Bryan B Hochster Howard S HS Lacy Jill J
British journal of cancer 20160301 7
<h4>Background</h4>Modifications of FOLFIRINOX are widely used despite the absence of prospective data validating efficacy in metastatic disease (metastatic pancreatic cancer (MPC)) or locally advanced pancreatic cancer (LAPC). We conducted a multicentre phase II study of modified FOLFIRINOX in advanced pancreatic cancer to assess the impact of dose attenuation in MPC and efficacy in LAPC.<h4>Methods</h4>Patients with untreated MPC or LAPC received modified FOLFIRINOX (irinotecan and bolus 5-flu ...[more]