Molecular patterns in human ulcerative colitis and correlation with response to infliximab.

ABSTRACT:

Background

As a T cell-mediated disease of the colonic epithelium, ulcerative colitis (UC) is likely to share pathogenic elements with other T cell-mediated inflammatory diseases. Recently, microarray analysis revealed large-scale molecular changes in T cell-mediated rejection of kidney and heart transplants. We hypothesized that similar disturbances might be operating in UC and could provide insights into responsiveness to therapy.

Methods

We studied 56 colon biopsies from patients with colitis characterizing the clinical and histological features and using microarrays to define the messenger RNA phenotype. We expressed the microarray results using previously defined pathogenesis-based transcript sets. We also studied 48 published microarray files from human colon biopsies

SUBMITTER: Halloran B 

PROVIDER: S-EPMC4985265 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature