Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC4985630 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20160816
Nucleosome breathing potentially increases the DNA exposure, which in turn recruits DNA-binding protein and regulates gene transcription. Numerous studies have shown the critical roles of N-terminal tails of histones H3 and H4 in gene expression; however, few studies have focused on the H2A C-terminal tail. Here we present thorough computational studies on a single nucleosome particle showing the linker DNA closing and opening, which is thought to be nucleosome breathing. With our simulation, th ...[more]