Ontology highlight
ABSTRACT:
SUBMITTER: Yeh CM
PROVIDER: S-EPMC4985659 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Yeh Chung-Min CM Chang Liang-Yu LY Lin Shu-Hui SH Chou Jian-Liang JL Hsieh Hsiao-Yen HY Zeng Li-Han LH Chuang Sheng-Yu SY Wang Hsiao-Wen HW Dittner Claudia C Lin Cheng-Yu CY Lin Jora M J JM Huang Yao-Ting YT Ng Enders K W EK Cheng Alfred S L AS Wu Shu-Fen SF Lin Jiayuh J Yeh Kun-Tu KT Chan Michael W Y MW Chan Michael W Y MW
Scientific reports 20160816
While aberrant JAK/STAT signaling is crucial to the development of gastric cancer (GC), its effects on epigenetic alterations of its transcriptional targets remains unclear. In this study, by expression microarrays coupled with bioinformatic analyses, we identified a putative STAT3 target gene, NR4A3 that was downregulated in MKN28 GC daughter cells overexpressing a constitutively activated STAT3 mutant (S16), as compared to an empty vector control (C9). Bisulphite pyrosequencing and demethylati ...[more]