Ontology highlight
ABSTRACT:
SUBMITTER: Cialfi S
PROVIDER: S-EPMC4985699 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cialfi Samantha S Le Pera Loredana L De Blasio Carlo C Mariano Germano G Palermo Rocco R Zonfrilli Azzurra A Uccelletti Daniela D Palleschi Claudio C Biolcati Gianfranco G Barbieri Luca L Screpanti Isabella I Talora Claudio C
Scientific reports 20160816
Mutation of the Golgi Ca(2+)-ATPase ATP2C1 is associated with deregulated calcium homeostasis and altered skin function. ATP2C1 mutations have been identified as having a causative role in Hailey-Hailey disease, an autosomal-dominant skin disorder. Here, we identified ATP2C1 as a crucial regulator of epidermal homeostasis through the regulation of oxidative stress. Upon ATP2C1 inactivation, oxidative stress and Notch1 activation were increased in cultured human keratinocytes. Using RNA-seq exper ...[more]