Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
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ABSTRACT:
SUBMITTER: Robinson EB
PROVIDER: S-EPMC4986048 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
Robinson Elise B EB St Pourcain Beate B Anttila Verneri V Kosmicki Jack A JA Bulik-Sullivan Brendan B Grove Jakob J Maller Julian J Samocha Kaitlin E KE Sanders Stephan J SJ Ripke Stephan S Martin Joanna J Hollegaard Mads V MV Werge Thomas T Hougaard David M DM Neale Benjamin M BM Evans David M DM Skuse David D Mortensen Preben Bo PB Børglum Anders D AD Ronald Angelica A Smith George Davey GD Daly Mark J MJ
Nature genetics 20160321 5
Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, ind ...[more]
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