Dataset Information

Study of seven single-nucleotide polymorphisms identified in East Asians for association with obesity in a Taiwanese population.

ABSTRACT: OBJECTIVE:This study aimed to examine single-nucleotide polymorphisms (SNPs) of seven previously reported obesity genes in East Asians and to analyse their associations and synergistic effects on obesity in the Taiwanese population. DESIGN:Cross-sectional study. SETTING:One medical centre in northern Taiwan. PARTICIPANTS:A total of 323 non-obese and 264 obese participants were recruited. The threshold for obesity in this study was a body mass index of ?27?kg/m(2), as defined by the Ministry of Health and Welfare in Taiwan. The study was performed with the approval of the institutional review board of MacKay Memorial Hospital, Taipei, Taiwan (application number 12MMHIS106). OUTCOME MEASURES:We analysed the genotype distributions of seven SNPs localising to the PPAR?2, GNB3, SDC3, ADRB2, FTO, PPAR? and ESR1 genes in obese and non-obese groups and then paired obesity-related SNPs to determine if they have synergistic effects on obesity. RESULTS:Analysis of the genotype distributions in obese and non-obese groups revealed only a significant positive correlation between an SNP in rs2282440-syndecan 3 (SDC3) and obesity in the Taiwanese population (p=0.006). In addition, the T/T genotype of SDC3 was significantly associated with a larger waist and hip circumference, higher body fat percentage and lower high-density lipoprotein cholesterol. Moreover, the combination of the rs2282440-SDC3T/T genotype with the rs1801282-peroxisome proliferator-activated receptor-gamma2 gene (PPAR?2) G carrier genotype was strongly associated with obesity (OR=6.77). CONCLUSIONS:We found that the rs2282440-SDC3T/T genotype is associated with obesity in the Taiwanese population. Furthermore, there is a synergistic effect of the high-risk alleles of the SDC3 and PPAR?2 genes on the obese phenotype in the Taiwanese population. TRIAL REGISTRATION NUMBER:12MMHIS106; Results.

SUBMITTER: Huang WH

PROVIDER: S-EPMC4986083 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Study of seven single-nucleotide polymorphisms identified in East Asians for association with obesity in a Taiwanese population.

Huang Wei-Hsin WH Hwang Lee-Ching LC Chan Hsin-Lung HL Lin Hsiang-Yu HY Lin Yung-Hsiang YH

BMJ open 20160810 8

<h4>Objective</h4>This study aimed to examine single-nucleotide polymorphisms (SNPs) of seven previously reported obesity genes in East Asians and to analyse their associations and synergistic effects on obesity in the Taiwanese population.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>One medical centre in northern Taiwan.<h4>Participants</h4>A total of 323 non-obese and 264 obese participants were recruited. The threshold for obesity in this study was a body mass index of ≥27 kg/m(2), as ...[more]

PMID: 27515755

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Project description:Obesity may aggravate the effects of sarcopenia on skeletal muscle structure and function in the elderly, but no study has attempted to identify the gene variants associated with sarcopenia in obese women. Therefore, the aims of the present study were to: (1) describe neuromuscular function in sarcopenic and non-sarcopenic women with or without obesity; (2) identify gene variants associated with sarcopenia in older obese women. In 307 Caucasian women (71 ± 6 years, 66.3 ± 11.3 kg), skeletal muscle mass was estimated using bioelectric impedance, and function was tested with a 30 s one-leg standing-balance test. Biceps brachii thickness and vastus lateralis cross-sectional area (VLACSA) were measured with B-mode ultrasonography. Handgrip strength, maximum voluntary contraction elbow flexion (MVCEF), and knee extension torque (MVCKE) were measured by dynamometry, and MVCKE/VLACSA was calculated. Genotyping was performed for 24 single-nucleotide polymorphisms (SNPs), selected based on their previous associations with muscle-related phenotypes. Based on sarcopenia and obesity thresholds, groups were classified as sarcopenic obese, non-sarcopenic obese, sarcopenic non-obese, or non-sarcopenic non-obese. A two-way analysis of covariance was used to assess the main effects of sarcopenia and obesity on muscle-related phenotypes and binary logistic regression was performed for each SNP to investigate associations with sarcopenia in obesity. There were no significant obesity * sarcopenic status interactions for any of the investigated muscle-related phenotypic parameters. Neither sarcopenia nor obesity had a significant effect on biceps brachii thickness, but sarcopenia was associated with lower VLACSA (p = 0.003). Obesity was associated with lower MVCEF (p = 0.032), MVCKE (p = 0.047), and MVCKE/VLACSA (p = 0.012) with no significant effect of sarcopenia. Adjusted for age and height, three SNPs (ACTN3 rs1815739, MTHFR rs1801131, and MTHFR rs1537516) were associated with sarcopenia in obese participants. Sarcopenia was associated with a smaller muscle size, while obesity resulted in a lower muscle quality irrespective of sarcopenia. Three gene variants (ACTN3 rs1815739, MTHFR rs1801131, and MTHFR rs1537516) suspected to affect muscle function, homocysteine metabolism, or DNA methylation, respectively, were associated with sarcopenia in obese elderly women. Understanding the skeletal muscle features affected by sarcopenia and obesity, and identification of genes related to sarcopenia in obese women, may facilitate early detection of individuals at particular risk of sarcopenic obesity.

Dataset Information

Study of seven single-nucleotide polymorphisms identified in East Asians for association with obesity in a Taiwanese population.

Publications

Study of seven single-nucleotide polymorphisms identified in East Asians for association with obesity in a Taiwanese population.

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