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A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System.

ABSTRACT: An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K2CO3 as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K2CO3 in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations.

SUBMITTER: Disale S

PROVIDER: S-EPMC4986413 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System.

Disale Shamrao S Kale Sandip S Abraham George G Kahandal Sandeep S Sawarkar Ashish N AN Gawande Manoj B MB

Frontiers in chemistry 20160816

An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K2CO3 as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K2CO3 in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (P ...[more]

PMID: 27579301

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