Ontology highlight
ABSTRACT:
SUBMITTER: Hashimoto-Tane A
PROVIDER: S-EPMC4986522 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Hashimoto-Tane Akiko A Sakuma Machie M Ike Hiroshi H Yokosuka Tadashi T Kimura Yayoi Y Ohara Osamu O Saito Takashi T
The Journal of experimental medicine 20160627 8
The immunological synapse (IS) formed at the interface between T cells and antigen-presenting cells represents a hallmark of initiation of acquired immunity. T cell activation is initiated at T cell receptor (TCR) microclusters (MCs), in which TCRs and signaling molecules assemble at the interface before IS formation. We found that each TCR-MC was transiently bordered by a ring structure made of integrin and focal adhesion molecules in the early phase of activation, which is similar in structure ...[more]