Ontology highlight
ABSTRACT:
SUBMITTER: Domanski M
PROVIDER: S-EPMC4986900 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Domanski Michal M Upla Paula P Rice William J WJ Molloy Kelly R KR Ketaren Natalia E NE Stokes David L DL Jensen Torben Heick TH Rout Michael P MP LaCava John J
RNA (New York, N.Y.) 20160711 9
As a result of its importance in key RNA metabolic processes, the ribonucleolytic RNA exosome complex has been the focus of intense study for almost two decades. Research on exosome subunit assembly, cofactor and substrate interaction, enzymatic catalysis and structure have largely been conducted using complexes produced in the yeast Saccharomyces cerevisiae or in bacteria. Here, we examine different populations of endogenous exosomes from human embryonic kidney (HEK) 293 cells and test their en ...[more]