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Fluorescence Dye Loaded Nano-graphene for Multimodal Imaging Guided Photothermal Therapy.

ABSTRACT: Photoacoustic imaging (PA) has emerged as a novel and noninvasive imaging modality owing to its high spatial resolution and high soft tissue contrast. Herein, we loaded a near-infrared (NIR) fluorescence dye (CySCOOH) onto the surface of PEGylated graphene oxide (GO) via ?-? stacking to increase the NIR absorbance of GO. The PA imaging proved that PEGylated GO-CysCOOH (GO-PEG-CysCOOH) significantly enhances the PA signal in the tumor site compared with free GO-PEG. We then utilized the strong optical absorbance of GO-PEG-CySCOOH in the NIR region for in vivo photothermal therapy, achieving efficient tumor ablation after intravenous injection of GO-PEG-CySCOOH and low-power laser irradiation on the tumor. Our results indicate that this graphene-based nanocomposite can be developed as a promising contrast agent for PA imaging and a thermal agent for imaging guided photothermal therapy.

SUBMITTER: Rong P

PROVIDER: S-EPMC4987095 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Fluorescence Dye Loaded Nano-graphene for Multimodal Imaging Guided Photothermal Therapy.

Rong Pengfei P Wu Jianzhen J Liu Zhiguo Z Ma Xiaoqian X Yu Lun L Zhou Kechao K Zeng Wenbin W Wang Wei W

RSC advances 20151221 3

Photoacoustic imaging (PA) has emerged as a novel and noninvasive imaging modality owing to its high spatial resolution and high soft tissue contrast. Herein, we loaded a near-infrared (NIR) fluorescence dye (CySCOOH) onto the surface of PEGylated graphene oxide (GO) via π-π stacking to increase the NIR absorbance of GO. The PA imaging proved that PEGylated GO-CysCOOH (GO-PEG-CysCOOH) significantly enhances the PA signal in the tumor site compared with free GO-PEG. We then utilized the strong op ...[more]

PMID: 27547385

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Dataset Information

Fluorescence Dye Loaded Nano-graphene for Multimodal Imaging Guided Photothermal Therapy.

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Fluorescence Dye Loaded Nano-graphene for Multimodal Imaging Guided Photothermal Therapy.

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