Ontology highlight
ABSTRACT:
SUBMITTER: Hossain M
PROVIDER: S-EPMC4987141 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Hossain Manzar M Stillman Bruce B
eLife 20160726
Newly born cells either continue to proliferate or exit the cell division cycle. This decision involves delaying expression of Cyclin E that promotes DNA replication. ORC1, the Origin Recognition Complex (ORC) large subunit, is inherited into newly born cells after it binds to condensing chromosomes during the preceding mitosis. We demonstrate that ORC1 represses Cyclin E gene (CCNE1) transcription, an E2F1 activated gene that is also repressed by the Retinoblastoma (RB) protein. ORC1 binds to R ...[more]