Ontology highlight
ABSTRACT:
SUBMITTER: Shaver TM
PROVIDER: S-EPMC4987189 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Shaver Timothy M TM Lehmann Brian D BD Beeler J Scott JS Li Chung-I CI Li Zhu Z Jin Hailing H Stricker Thomas P TP Shyr Yu Y Pietenpol Jennifer A JA
Cancer research 20160526 16
Triple-negative breast cancer (TNBC) and other molecularly heterogeneous malignancies present a significant clinical challenge due to a lack of high-frequency "driver" alterations amenable to therapeutic intervention. These cancers often exhibit genomic instability, resulting in chromosomal rearrangements that affect the structure and expression of protein-coding genes. However, identification of these rearrangements remains technically challenging. Using a newly developed approach that quantita ...[more]