Ontology highlight
ABSTRACT:
SUBMITTER: Karanasios E
PROVIDER: S-EPMC4987534 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Karanasios Eleftherios E Walker Simon A SA Okkenhaug Hanneke H Manifava Maria M Hummel Eric E Zimmermann Hans H Ahmed Qashif Q Domart Marie-Charlotte MC Collinson Lucy L Ktistakis Nicholas T NT
Nature communications 20160811
Autophagosome formation requires sequential translocation of autophagy-specific proteins to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest autophagy-specific structure forming de novo is a small punctum of the ULK1 complex. The provenance of this structure and its mode of formation are unknown. We show that the ULK1 structure emerges from regions, where ATG9 vesicles align with the ER and its formation requires ER exit and coatomer function. Super-resolution mic ...[more]