Ontology highlight
ABSTRACT:
SUBMITTER: Kawasaki Y
PROVIDER: S-EPMC4987620 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kawasaki Yuki Y Sakimura Ayaka A Park Chul Min CM Tomaru Rika R Tanaka Tomohiro T Ozawa Tatsuhiko T Zhou Yue Y Narita Kaori K Kishi Hiroyuki H Muraguchi Atsushi A Sakurai Hiroaki H
Scientific reports 20160817
Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodimer, the most potent ErbB receptor dimer. Constitutive tyrosine phosphorylation of ErbB2 and ErbB3 was significantly decreased in phorbol ester- and growth factor-treated BT-474 and M ...[more]