PepComposer: computational design of peptides binding to a given protein surface.
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ABSTRACT:
SUBMITTER: Obarska-Kosinska A
PROVIDER: S-EPMC4987918 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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PepComposer: computational design of peptides binding to a given protein surface.
Obarska-Kosinska Agnieszka A Iacoangeli Alfredo A Lepore Rosalba R Tramontano Anna A
Nucleic acids research 20160430 W1
There is a wide interest in designing peptides able to bind to a specific region of a protein with the aim of interfering with a known interaction or as starting point for the design of inhibitors. Here we describe PepComposer, a new pipeline for the computational design of peptides binding to a given protein surface. PepComposer only requires the target protein structure and an approximate definition of the binding site as input. We first retrieve a set of peptide backbone scaffolds from monome ...[more]
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