Ontology highlight
ABSTRACT:
SUBMITTER: Satta G
PROVIDER: S-EPMC4988016 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Satta Giovanni G Witney Adam A AA Shorten Robert J RJ Karlikowska Magdalena M Lipman Marc M McHugh Timothy D TD
BMC medicine 20160816 1
<h4>Background</h4>The largest outbreak of isoniazid-resistant (INH-R) Mycobacterium tuberculosis in Western Europe is centred in North London, with over 400 cases diagnosed since 1995. In the current study, we evaluated the genetic variation in a subset of clinical samples from the outbreak with the hypothesis that these isolates have unique biological characteristics that have served to prolong the outbreak.<h4>Methods</h4>Fitness assays, mutation rate estimation, and whole-genome sequencing w ...[more]