Ontology highlight
ABSTRACT:
SUBMITTER: Tsai SY
PROVIDER: S-EPMC4988876 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Tsai Shih-Yin SY Rodriguez Ariana A AA Dastidar Somasish G SG Del Greco Elizabeth E Carr Kaili Lia KL Sitzmann Joanna M JM Academia Emmeline C EC Viray Christian Michael CM Martinez Lizbeth Leon LL Kaplowitz Brian Stephen BS Ashe Travis D TD La Spada Albert R AR Kennedy Brian K BK
Cell reports 20160804 7
Obesity is a major risk factor driving the global type II diabetes pandemic. However, the molecular factors linking obesity to disease remain to be elucidated. Gender differences are apparent in humans and are also observed in murine models. Here, we link these differences to expression of eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1), which, upon HFD feeding, becomes significantly reduced in the skeletal muscle and adipose tissue of male but not female mice. Strikingly, ...[more]