Ontology highlight
ABSTRACT:
SUBMITTER: Tenaillon O
PROVIDER: S-EPMC4988878 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Nature 20160801 7615
Adaptation by natural selection depends on the rates, effects and interactions of many mutations, making it difficult to determine what proportion of mutations in an evolving lineage are beneficial. Here we analysed 264 complete genomes from 12 Escherichia coli populations to characterize their dynamics over 50,000 generations. The populations that retained the ancestral mutation rate support a model in which most fixed mutations are beneficial, the fraction of beneficial mutations declines as f ...[more]