Ontology highlight
ABSTRACT:
SUBMITTER: Lin HC
PROVIDER: S-EPMC4988905 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Lin Hsiao-Ching HC McMahon Travis C TC Patel Ashay A Corsello Michael M Simon Adam A Xu Wei W Zhao Muxun M Houk K N KN Garg Neil K NK Tang Yi Y
Journal of the American Chemical Society 20160318 12
Dimeric indole alkaloids are structurally diverse natural products that have attracted significant attention from the synthetic and biosynthetic communities. Here, we describe the characterization of a P450 monooxygenase CnsC from Penicillium that catalyzes the heterodimeric coupling between two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold. We show, via biochemical characterization, substrat ...[more]