Ontology highlight
ABSTRACT:
SUBMITTER: Timmer MR
PROVIDER: S-EPMC4988941 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Timmer Margriet R MR Martinez Pierre P Lau Chiu T CT Westra Wytske M WM Calpe Silvia S Rygiel Agnieszka M AM Rosmolen Wilda D WD Meijer Sybren L SL Ten Kate Fiebo J W FJ Dijkgraaf Marcel G W MG Mallant-Hent Rosalie C RC Naber Anton H J AH van Oijen Arnoud H A M AH Baak Lubbertus C LC Scholten Pieter P Böhmer Clarisse J M CJ Fockens Paul P Maley Carlo C CC Graham Trevor A TA Bergman Jacques J G H M JJ Krishnadath Kausilia K KK
Gut 20150623 10
<h4>Objective</h4>The risk of developing adenocarcinoma in non-dysplastic Barrett's oesophagus is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers.<h4>Methods</h4>In a prospective cohort of patients with non-dysplastic Barrett's oesophagus, we evaluated six molecular markers: p16, p53, Her-2/neu, 20q, MYC and aneusomy by DN ...[more]