Ontology highlight
ABSTRACT:
SUBMITTER: Willems SM
PROVIDER: S-EPMC4989214 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Willems Sara M SM Cornes Belinda K BK Brody Jennifer A JA Morrison Alanna C AC Lipovich Leonard L Dauriz Marco M Chen Yuning Y Liu Ching-Ti CT Rybin Denis V DV Gibbs Richard A RA Muzny Donna D Pankow James S JS Psaty Bruce M BM Boerwinkle Eric E Rotter Jerome I JI Siscovick David S DS Vasan Ramachandran S RS Kaplan Robert C RC Isaacs Aaron A Dupuis Josée J van Duijn Cornelia M CM Meigs James B JB
European journal of human genetics : EJHG 20160210 9
Insulin-like growth factor 1 (IGF-I) has been associated with insulin resistance. Genome-wide association studies (GWASs) of fasting insulin (FI) identified single-nucleotide variants (SNVs) near the IGF1 gene, raising two hypotheses: (1) these associations are mediated by IGF-I levels and (2) these noncoding variants either tag other functional variants in the region or are directly functional. In our study, analyses including 5141 individuals from population-based cohorts suggest that FI assoc ...[more]