Ontology highlight
ABSTRACT:
SUBMITTER: Al-Obaidi N
PROVIDER: S-EPMC4990065 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Al-Obaidi Naowras N Mitchison Timothy J TJ Crews Craig M CM Mayer Thomas U TU
ACS chemical biology 20160428 6
The genetic integrity of each organism is intimately tied to the correct segregation of its genome during mitosis. Insights into the underlying mechanisms are fundamental for both basic research and the development of novel strategies to treat mitosis-relevant diseases such as cancer. Due to their fast mode of action, small molecules are invaluable tools to dissect mitosis. Yet, there is a great demand for novel antimitotic compounds. We performed a chemical genetic suppression screen to identif ...[more]