Ontology highlight
ABSTRACT:
SUBMITTER: Eadie LN
PROVIDER: S-EPMC4990177 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Eadie Laura N LN Hughes Timothy P TP White Deborah L DL
PloS one 20160818 8
The tyrosine kinase inhibitor (TKI) imatinib has resulted in excellent responses in the majority of Chronic Myeloid Leukaemia (CML) patients; however, resistance is observed in 20-30% of patients. More recently, resistance to the second generation TKIs, nilotinib and dasatinib, has also been observed albeit at a lower incidence. ABCB1 has previously been implicated in TKI export and its overexpression linked to TKI resistance. In this study the dynamics of nilotinib resistance was studied in CML ...[more]